Robert Franz: Vorträge - Diabetes: Chrom Picolinat, Vitamin C und Vitamin D3
The present invention relates to antioxidants, mixtures, preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, food and feed and other solids or liquids or mixtures thereof, the 3,3'-dihydroxyisorenieratin, isorenieratin-3,3'- Dichinone, 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone, 3,3'-dihydroxy-2,2', 4,4'-tetra-tert-butylisorenieratin or related isorenieratin Containing compounds or using these compounds or with a method ob es sprat bei Typ 2 Diabetes includes the use of these compounds were prepared.
The The present invention relates to antioxidants, mixtures, preparations, dye, Vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, Food and feed as well as other solids or liquids or mixtures thereof, the 3,3'-dihydroxyisorenieratin, Isorenieratin-3,3'-dichinone, 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone, 3,3'-dihydroxy-2,2', 4,4'-tetra tert-butylisorenieratin or related isorenieratin compounds contained or using these compounds or with a process, which contained the use of these compounds.
It is therefore to be understood that the foregoing and the following yet to be explained Features of the subject invention not only in the specified special combination but can also be used in other combinations, without the framework of To leave invention. In particular, preferred embodiments can be combined with each other. In ob es sprat bei Typ 2 Diabetes, many of the yellow to red colored carotenoids come as natural product in starting products of food and feed.
Thus, carotenoids in colorants and carotenoid formulations can be used for human consumption. The font DE 02 A1 describes colorants from carotenoid aggregates. It It goes without saying that a wide range of application demands are high to the corresponding carotenoids, these often do not in the desired Comply with the scope can.
Especially properties like availability, Stability, solubility and antioxidant effects of course Occurring carotenoids are often not sufficient to make it technically usable.
A previously used antioxidant carotenoid is astaxanthin. It is widely used as a dye with antioxidant effect in food and feed. Furthermore, there are research results showing the positive effects of astaxanthin on, for example, the immune system, kidneys, eyes, nerves, veins as well as diabetes, cancer, hypertension and a general anti-inflammatory effect Ghazi Nussein et al.
In order to improve the solubility of astaxanthin in an aqueous medium, derivatives of astaxanthin are generally used for this purpose. Here, the astaxanthin is derivatized with easily cleavable protecting groups. According to a scientific publication, the synthetic carotenoid 3,3'-dihydroxy-2,2 ', 4,4'-tetra-tert-butylisorenieratin BHT ob es sprat bei Typ 2 Diabetes has good antioxidant properties US Pat.
Beutner, S. A technical use of this compound, in particular in dermocosmetics, Pharmaceuticals, foodstuffs and in particular in higher concentrations was not revealed. One of the objects of the present invention has been to find carotenoids which are versatile and widely applicable and readily available for technical applications.
On the one hand, it was the task of providing well-tolerated carotenoids for humans and animals, which are not only used in dermocosmetics, food and animal feed and protect them against oxidative influences, but possibly also through their superior antioxidant activity and good health properties the healthy the state of human and animal health can be prophylactically or therapeutically positively influenced by their use in dermocosmetics, food and feed.
On the other hand, the object was to provide carotenoids which can be used with good antioxidant activity in low concentrations and ob es sprat bei Typ 2 Diabetes offer the possibility of an undesirable color effect, especially for applications in the dermocosmetic or pharmaceutical sector, in food or feed or in Mixtures, preparations, vesicles, colorants or carotenoid formulations. On the other hand, a further aspect of the task was to achieve attractive color effects on the basis of these carotenoids, especially by means of this color effect, and to allow this, in particular, at the same time as good compatibility with humans and animals.
A further object was to provide carotenoids which, alone or in mixtures with other carotenoids, form aggregates with color-stabilizing or vesicle- or lipid-phase-stabilizing action and thus can be used advantageously in colorants, vesicles or other lipid phases. The resulting items The invention will be described in the course of the invention disclosure.
Isorenieratin compounds or compounds I are compounds of the general formula I. Easily cleavable protecting groups are linked, for example, via ether compounds or ester compounds and are preferably tocopherol, resveratrol or alkyl or alkenecarboxylic acids, such as oleic acid, palmitate, ascorbate, succinate, acetylsalicylate or amino acids, such as lysine.
Isorenieratin-3,3'-dichinone or compound II is a compound of the formula II :. As carotenoids are also understood the oxygenated xanthophylls. The above connections V fall into the class of carotenoids. Unless the above Compounds V in addition to other carotenoids z. Explicitly included are perfumes and decorative cosmetics, such as kohl pencils, mascara, eyeshadows, tinted day creams, powders, concealers, blushes, lipsticks, lip pencils, makeup, nail polish or glamor gel. Also included ob es sprat bei Typ 2 Diabetes skin care compositions in which the pharmaceutically dermatological application takes into account cosmetic considerations is reached.
Such dermocosmetics are used for the support, prevention and treatment of skin diseases and can develop a biological effect in addition to the cosmetic effect. Dermocosmetics contain in a cosmetically acceptable medium suitable auxiliaries and additives, which are chosen with regard to the specific field of application. Such auxiliaries and additives are familiar to the expert and can, for. Such agents are for. As further dermocosmetic agents can be used for example: acetylsalicylic acid, atropine, azulene, hydrocortisone and its derivatives, eg.
As hydrocortisone valerate, vitamins of the B and D series, especially vitamin B 1 ob es sprat bei Typ 2 Diabetes, vitamin B 12vitamin D, vitamin A or its derivatives such as retinyl palmitate, vitamin E or its derivatives such. As tocopheryl acetate, vitamin C and its derivatives such. As ascorbyl glucoside but also niacinamide, panthenol, bisabolol, polydocanol, unsaturated fatty acids such. Preferred NO synthase inhibitor is nitroarginine.
In front The active substance s selected from the group comprising catechins and bile acid esters of catechins and aqueous or organic extracts from plants or plant parts which have a content of catechins or bile acid esters of catechins are also suitable.
Also advantageous are their typical ingredients eg polyphenols or catechins, caffeine, vitamins, sugars, minerals, amino acids, lipids. Catechins represent a group of compounds which are to be regarded as hydrogenated flavones or anthocyanidins and derivatives of "catechin" catechol, 3,3 ', 4', 5,7-flavanpentaol, 2- 3,4-dihydroxyphenyl -chroman Also, epicatechin 2R, 3R -3,3 ', 4', 5,7-flavanpentaol is an advantageous active ingredient in the context of the present invention a content of catechins, in particular extracts of green tea, such as extracts from leaves of the plants of the species Camellia spec.
Unless the above compounds V during the Production of dermocosmetics are used or in dermocosmetics are contained under cosmetically acceptable media only substances be understood that the above compounds V not include.
Even if the compounds V generally do not cause irritation or damage on contact with human or animal skin tissue or hair, in the following the compounds V should not be included in the term of the cosmetically acceptable substances. Flavones and their derivatives often collectively called "flavones" are also advantageous dermocosmetic active substances in the context of the present invention.
Some of the more important flavones, which can also be used with preference in formulations according to the invention, have ob es sprat bei Typ 2 Diabetes or more ob es sprat bei Typ 2 Diabetes Z, for example one to six substituents Z, where Z ob es sprat bei Typ 2 Diabetes in particular be an OH group, as listed in Table 1 below. Artificially skin-tanning dermocosmetic agents that are suitable for the skin without natural or artificial To irradiate irradiation with UV rays, z.
Suitable Kerstin-hardening substances are usually dermocosmetic agents, as in antiperspirants be used, such. Potassium aluminum sulfate, aluminum hydroxychloride, Aluminum lactate. When Peroxide decomposers can Substances from the most diverse substance classes are used. It goes without saying that for applications to humans and Animal only substances used in the used Concentrations usually no harmful effect to have.
The sulfur and phosphorous containing compounds may be more organic or inorganic nature, being substances of an organic nature are preferred.
Whether certain compounds as Peroxidzersetzer For example, it is recognized in vitro that they are useful in Room temperature, dissolved in a molar concentration of 0. Peroxidzersetzer containing classes of substances are, for example: Mercaptans, dialkyl, diaryl, or arylalkyl sulfides, dialkyl disulfides, Dialkyl sulfoxides, sulfinic acids, and their esters and amides, sulfenic acid esters or amides, thioesters, thioamides, Thioureas, thiocarbonyl compounds, thioacetals or ketals also in cyclic form.
Pyridinethiolcarboxylic acid, 2-methoxy-pyrimidinol-carboxylic acids, 2-methoxypyridinecarboxylic acids, 2-dimethylamino-pyrimidinolcarboxylic acids, 2-dimethylaminopyridinecarboxylic acids. Further examples are in the writings WO and WO described. Radical decomposers or radical scavengers are substances that can disrupt radical reaction chains by reacting with radicals and neutralizing them.
Such radicals are for example hydroxy radicals, radical photoproducts or singlet oxygen. The compounds V can ob es sprat bei Typ 2 Diabetes used as antioxidants. Unless the above connections V In addition to antioxidants used, these antioxidants just mean more antioxidants than those mentioned above Do not include compounds V.
As antimicrobial agents and preservatives can for example, usual, known to the expert antimicrobial agents and preservatives, such as p-hydroxybenzoic acid ester, Imidazolidinyl urea, formaldehyde, sorbic acid, benzoic acid, salicylic acid, etc.
Such deodorizing substances are z. Further suitable antimicrobial agents are: Table 2: suitable antimicrobial agents. Other antimicrobial agents and preservatives are also suitable, in particular, they are suitable to be incorporated into the dermocosmetics and pharmaceuticals according to the invention.
Advantageous substances are, for example, 2,4,4'-trichloro-2'-hydroxydiphenyl ether Irgasan1,6-di- 4-chlorophenylbiguanido hexane chlorhexidine3,4,4'-trichlorocarbanilide, quaternary ammonium compoundsClove oil, mint oil, thyme oil, triethyl citrate, farnesol 3,7,trimethyl-2,6,dodecatrienol and those disclosed in the patent publications DE 40 DE 38 DE 04 DE 29 DE 09 DE 11 DE 41 DE ob es sprat bei Typ 2 Diabetes DE 47 Ob es sprat bei Typ 2 Diabetes 02 DE 31 DE 37 DE 24 DE 23 and DE 16 described active ingredients or drug combinations.
Also, sodium bicarbonate is advantageous to use. Likewise, microbial polypeptides can be used. Others are: Dibromodicyanobutane 2-bromobromomethyl-glutarodinitrile3-iodopropynyl butyl carbamate, 2-bromonitro-propane-1,3-diol, imidazolidinyl urea, 5-chloromethylisothiazoline one, 2-chloroacetamide, benzalkonium chloride and benzyl alcohol suitable.
Further, phenylhydroxyalkyl ethers, especially the compound known as phenoxyethanol, are useful as antimicrobial agents and preservatives because of their bactericidal and fungicidal effects on a number of microorganisms.
Perfume oils are usually mixtures of natural and synthetic fragrances, which are used for example in perfumes. Natural sources of substances that are suitable as fragrances are extracts of flowers, such as lily, lavender, rose, jasmine, neroli, ylang-ylang, stems and leaves, such as geranium, patchouli, ob es sprat bei Typ 2 Diabetes, fruits, such as anise, corianderCaraway, juniper, fruit peel, for example, ob es sprat bei Typ 2 Diabetes bergamot, lemon, orange, roots, such as mace, angelics, celery, kar damon, Costus, Iris, Calmus, wood, such as pine, sandal, guaiac, cedar, rosewood, herbs and grasses, for example tarragon, lemongrass, sage, thyme, needles and twigs, for example of spruce, fir, pine, Pines, resins and balms, such as galbanum, elemi, benzoin, myrrh, olibanum, opoponax.
Furthermore, animal raw materials come into consideration, such as civet and Castoreum. Typical synthetic substances which are used as fragrances are products of the type of esters, ethers, aldehydes, ketones, alcohols and hydrocarbons. Examples of ester-type fragrance compounds are benzyl acetate, phenoxyethyl isobutyrate, 4-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinylacetate, phenylethyl acetate, linalyl benzoate, benzylformate, ethylmethylphenylglycinate, allylcyclohexylpropionate, styrallylpropionate and benzylsalicylate.
The ethers include, for example, benzyl ethyl ether, to the aldehydes, for example, the alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeonate, to the ketones, for example, the ionones, cc-isomethyl ions and methyl cedryl ketone to the alcohols Anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terioneol, the hydrocarbons mainly include the terpenes and balsams.
Preferably, ob es sprat bei Typ 2 Diabetes, who uses mixtures of different substances as fragrances, which together produce an attractive fragrance. Also essential oils of lower volatility, which are mostly used as aroma components, are suitable as perfume oils or ob es sprat bei Typ 2 Diabetes, such as sage oil, camomile oil, clove oil, lemon balm oil, mint oil, cinnamon oil, lime blossom oil, juniper berry oil, vetiver oil, oliban oil, galbanum oil, labolanum oil and lavandin oil.
So flavors can contain substances, also as perfume oil or fragrance can be used. Flavors can be next to a variety of flavors contain other substances, for example Solvents Carriers, Preservatives and antioxidants. Flavorings can be made natural Flavored, nature-identical flavors, artificial flavors, aroma extracts, Reaction flavors and smoke flavors exist.
Preferred flavorings are natural Flavorings, nature-identical flavors and artificial flavors. Pentasulfides, trithiolanes, Thioesters, alkenals, glucosinolates or isothiocyanates. Z hexenol, E, Z -2,6-nonadienal, E - u.
When Waxes can For example, carnauba wax, candililla wax, Beeswax, microcrystalline wax, ozokerite wax and Ca, Mg and Al oleates, myristates, linoleates and stearates. The fatty acid triglycerides can be selected, for example, advantageously from the group of synthetic, semi-synthetic and natural oils, such as.